Andrzej K. Siwicki, Elżbieta Terech-Majewska
ABSTRACT. The IHN virus induces high mortality among fishes, especial rainbow trout fingerlings. This study focuses on the in vitro influence of IHN virus on spleen phagocyte activity and the proliferative response of pronephros lymphocytes stimulated by mitogens ConA and LPS. The results indicate that the IHN virus decreased the metabolic activity (RBA) and potential killing activity (PKA) of spleen phagocytes statistically significantly (P<0.05). A similar pattern was observed in lymphocyte activity, with the IHN virus statistically significantly (P<0.05) decreasing the proliferative response of pronephros lymphocytes stimulated by mitogens ConA and LPS. The results of this study showed that IHN virus suppressed cell-mediated immunity in rainbow trout.
Keywords: IHN, rainbow trout, etiology, pathogenesis, phagocyte and lymphocyte activity
Przyjęto po recenzji 24.11.2011 r.